What does every fisherman want? They want to be where the fish are and want a plentiful supply of fish. And what do conservationists want? They want to ensure that the wild salmon runs in Alaska, the Pacific Northwest, Japan and Siberia remain strong. A group of pioneering researchers has developed an innovative DNA profiling approach that helps grant both fishermen and conservationists their wish. Read more...
BioMark™ Customers, Press Releases and Publications
2009 Nov 23. The nuclear receptor DHR96 acts as a sentinel for low cholesterol concentrations in Drosophila. Mol Cell Biol.
. 2009. Morpholino-mediated gene knockdown in the early mouse embryo. Nat Prot [Protocols Network]
. 2009 July 7. Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database. Mol Cancer Ther. 8(7):2057-66
. 2009 Jun. Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med. 15(6):696-700.
. 2009 May 21. Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro. PLoS ONE. 4(5):e5654
. 2009 May. Microfluidic digital PCR enables rapid prenatal diagnosis of fetal aneuploidy. Am J Obstet Gynecol. 200(5):543.e1-7
. 2009 May 12. Integrative analysis of genome-wide RNA interference screens. Sci Signal. 2(70):pt4.
2009 May 8. High-throughput sequencing of the zebrafish antibody repertoire. Science. 324(5928):807-10. [Editor's Note: The SlingShot™ Kit from Fluidigm was used in this project to quantitiate samples for sequencing]
. 2009 May. Single molecule detection in nanofluidic digital array enables accurate measurement of DNA copy number. Anal Bioanal Chem. 394(2):457-67.
2009 Apr 9. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 458(7239):780-3. Download pdf
. 2009 Apr 2. An efficient platform for screening expression and crystallization of glycoproteins produced in human cells. Nat Protoc. 4(4):592-604.
. 2009 Mar 31. Genetic dissection of a major mouse obesity QTL (Carfhg2): Integration of gene expression and causality modeling. Physiol Genomics.
. 2009 Mar 19. Digital PCR provides sensitive and absolute calibration for high throughput sequencing. BMC Genomics. 10(1):116.
. 2009 Mar 15. Single-Molecule Detection of Epidermal Growth Factor Receptor Mutations in Plasma by Microfluidics Digital PCR in Non-Small Cell Lung Cancer Patients. Clin Cancer Res. 15(6):2076-2084.
. 2009 Jan. Noninvasive prenatal detection of fetal chromosomal aneuploidies by maternal plasma nucleic acid analysis: a review of the current
state of the art. BJOG. 116:152–157. [Editor’s Note: “..automated platforms for conducting digital PCR…” referenced in this paper (p156) is the Fluidigm BioMark Real Time System and Fluidigm 12.765 Digital Arrays”]
2008
, 2008 Dec 31. A Novel and Critical Role for Oct4 as a Regulator of the Maternal-Embryonic Transition. PLoS ONE.3(12): e4109.
, 2008 Dec. Digital PCR: a powerful new tool for noninvasive prenatal diagnosis? Prenat Diagn. 28(12):1087-93.
, 2008 Dec. Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. Aging Cell. 7(6):850-65.
, 2008 Nov 11. New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Sci Signal. 1(45):ra12.
, 2008 Nov 5. Development of potential pharmacodynamic and diagnostic markers for anti-IFN-α monoclonal antibody trials in systemic lupus erythematosus. Human Genomics and Proteomics, 2009: 16 pages Download pdf
, 2008 Nov, In-depth characterization of the microRNA transcriptome in a leukemia progression model. Genome Res. 18(11):1787-97.
, Nov-Dec 2008, Go with the (micro) flow. IEEE Potentials. 27(6):17-25.
, 2008 Oct 27. Computation of Maximal Resolution of Copy Number Variation on a Nanofluidic Device using Digital PCR. arXiv:0809.1460v2 [q-bio.GN]
2008 Oct 21. Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood. PNAS. 105(42):16266-71.
, 2008 Oct 1. Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo. Genes Dev. 22(19):2692-706
2008 Oct. Studying copy number variations using a nanofluidic platform. Nucleic Acids Research. 36(18):e116.
2008 Aug. DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight. Nucleic Acids Research. 36(14):4689-98.
2008 Aug 14. Microfluidics Digital PCR Reveals a Higher than Expected Fraction of Fetal DNA in Maternal Plasma. Clinical Chemistry. Download pdf
2008 Aug 6. Mathematical Analysis of Copy Number Variation in a DNA Sample Using Digital PCR on a Nanofluidic Device. PLoS ONE. 3(8): e2876.
2008 Jul 16. Type I Interferon: Potential Therapeutic Target for
Psoriasis? PLoSONE. 3(7):e2737.
2008 Jul 10. Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia using a novel nanofluidic platform and mutation-specific PCR. Leukemia.
2008 May 31. Current status of CNV research and related methods. Clinical Genome Research (Japan). 229(9)
2008 Feb 27. High throughput gene expression measurement with real time PCR in a microfluidic dynamic array. PLoSONE. 3(2):e1662.
2007
2007 Dec. Post-season stock composition analysis of Upper Cook Inlet sockeye salmon harvest, 2005-2007. Alaska Department of Fish and Game, Fishery Manuscript No.07-07, Anchorage.
2007 Nov 26. Intracellular expression profiles measured by real-time PCR tomography in the Xenopus laevis oocyte. Nucleic Acids Research. 36(2): 387–392.
2007 Oct 1. Detection of aneuploidy with digital polymerase chain reaction. Anal. Chem. 79(19):7576-9.
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