BioMark™ Customers, Press Releases and Publications
Customers
Here are just some of our growing number of customers:
- Alaska Department of Fish & Game
- The Chinese University of Hong Kong
- Eisai Co.
- The Fred Hutchinson Cancer Research Center
- ICx Biosystems
- In-Q-Tel
- Leiden University Medical Center
- MedImmune, Inc.
- National Cancer Institute – SAIC Frederick
- The University of Hong Kong
Press Releases
2009
2008
- December 16, 2008
Fluidigm and Stemgent Awarded One of CIRM’S First Grants to the Biotech Industry
California’s Stem Cell Agency Invests in Cell Culture Integrated Fluidic Circuit System
- December 1, 2008
Fluidigm Secures Licenses to Key Inventions for Detecting Fetal Genetic Characteristics in Maternal Plasma
- November 17, 2008
Fluidigm's Third Quarter Product Revenue Triples
Record Chip and Systems Unit Sales
- October 7, 2008
Stanford University Uses Fluidigm Integrated Fluidic Circuits to Help Develop Maternal Blood Test for Fetal Chromosomal Abnormalities
Scientists Find a Noninvasive Prenatal Test for Down Syndrome
- October 7, 2008
Enza Chooses Fluidigm BioMark™ System to Help Assure Core Seed Quality
- August 27, 2008
LGC Invests in Fluidigm's Integrated Fluidic Circuit Technology
First BioMark™ System for Genetic Analysis in the UK
- August 21, 2008
Fluidigm and Millenium Science Team Up in Australia and New Zealand Distribution Deal
- August 21, 2008
Fluidigm and Bio-Gene Technology Join Forces in Hong Kong Distribution Deal
- July 10, 2008
Hutchison Cancer Research Center Researcher Develops Method for Early Detection of Leukemia Relapse
Fluidigm Digital Arrays Allow 1000X Improvement in Detection Sensitivity of PCR Reactions
- June 16, 2008
National Cancer Institute Utilizing Fluidigm's 96.96 Dynamic Array for Rapid, Cost-Effective Follow Up to Whole-Genome SNP Assocaition Scans
Integrated Fluidic Circuits to Help Accelerate Publishing of Most-Promising Genetic Susceptibility Markers
- June 12, 2008
Fluidigm and the Ludwig Institute for Cancer Research Join Forces to Measure Expression of 900 Genes in 96 Samples in One Week
New 96.96 Dynamic Array make Discovery Through Validation Efforts Fast and Feasible
- June 2, 2008
Fluidigm Introduces First Integrated Fluidic Circuit Able to Perform 9,216 Simultaneous Real-Time PCR Experiments
New Generation BioMark™ 96.96 Dynamic Array Ushers in 24X Increase in Throughput Over Conventional System
- May 14, 2008
Fluidigm and Witec AG Join Forces in Swiss Distribution Deal
Arrangement Brings Integrated Fluidic Circuit Technology to Swiss Scientists Specializing in Real-Time PCR, Genotyping, Cancer Detection and Absolute Quantification
- May 12, 2008
Hazelle Lam Joins Fluidigm as One of Its Regional Sales Directors for Asia
- May 7, 2008
Fluidigm and AME Bioscience Team Up in Nordic Distribution Deal
Arrangement Brings Integrated Fluidic Circuit Technology to Nordic Scientists Specializing in Real-Time PCR, Genotyping, Cancer Detection and Absolute Quantification
- April 28, 2008
Fluidigm Launches New BioMark™ IFC Controller MX
Targeted for High-throughput Genetic Analysis
- April 14, 2008
Fluidigm Files Registration Statement for Proposed Initial Public Offering
2007
- October 15, 2007
Fluidigm Technology to Help Pioneering Researchers Sustain Pacific Rim Salmon Populations
Company’s Integrated Fluidic Circuits Allow DNA Profiling Six Times Faster With an 80 Percent Reduction in Total Cost.
- September 4, 2007
The NCI to Identify Germ-Line Markers of Cancer Susceptibility Using The BioMark System, Fluidigm Announces
BioMark™ dynamic arrays boost genotyping efficiency for projects encompassing 30-300 markers and 1,000 or more individual samples.
- August 29, 2007
Human Genetics Department at Leiden University Medical Center (LUMC) Adopts Fluidigm BioMark Real-Time PCR System
Busy core facility to use new BioMark™ dynamic arrays for high-throughput multiplexed analyses.
- August 2, 2007
Bioké and Fluidigm Announce Benelux Distributorship for BioMark System for Real-Time PCR and Genotyping
- July 18, 2007
Alaska Department of Fish and Game Adopts Fluidigm Technology to Speed Up Salmon Genotyping
Fluidigm’s BioMark™ Dynamic Arrays Allow Salmon Genotyping at Exponential Increases in Throughput.
- June 15, 2007
Fluidigm Launches New BioMark™ Dynamic Arrays For High-Throughput 5’-Nuclease Genotyping
- June 13, 2007
Fluidigm Announces Technical Breakthrough that Solves Fundamental Obstacle with Microfluidics in Life Science
- June 1, 2007
University of Queensland Researchers Solve Structure of the Munc18C/Syntaxin4 Complex Using the Fluidigm TOPAZ® System
- May 22, 2007
Fluidigm TOPAZ® System Used to Solve Structure of PLK1 Protein
- May 21, 2007
Fluidigm Announces that the Chinese University of Hong Kong has Selected the BioMark System for a Range of Molecular Diagnostic Applications
- May 18, 2007
Fluidigm Announces New BioMark Users in North America and Asia
- April 19, 2007
The Fred Hutchinson Cancer Research Center Adopts the BioMark System for Early Detection and Monitoring of Cancer
- January 22, 2007
Dominique Remy-Renou to Lead European Sales and Support for Fluidigm
- January 8, 2007
Fluidigm Raises $37 Million to Date in Series E Financings
2006
- December 18, 2006
Fluidigm Introduces BioMark Digital Arrays for Fast, Easy Digital PCR
- December 11, 2006
Fluidigm Announces New Addition to its Scientific Advisory Board: Frank McCormick, Ph.D., F.R.S.
- December 4, 2006
Article in Science Introduces New Application for BioMark Digital Arrays from Fluidigm
- November 27, 2006
Fluidigm Launches BioMark System to Shake Up Billion Dollar Market for Real-Time qPCR Assay
New system delivers six-fold increase in throughput relative to conventional high throughput gene expression offerings
- November 21, 2006
PNAS Article Validates BioMark Digital Arrays for Profiling Transcription Factors from a Single Stem Cell
Nanofluidic chips from Fluidigm Corporation achieve absolute quantification of cDNA copies
- November 20, 2006
Fluidigm and Berkeley Lab Awarded Phase II STTR Grant to Develop Microfluidic Chip for in-Situ Diffraction of Protein Crystals
- November 7, 2006
Fluidigm TOPAZ® System Instrumental in Solving Asf1 Structure, Advancing Research in Cancer and Genetic Disease
- October 20, 2006
Pam Morley to Serve as Fluidigm Vice President, Sales, Service, and Support for North America
- August 29, 2006
Fluidigm-Singapore Completes Final Milestone Toward Full Manufacturing Operations
Off-shore fab positions Fluidigm to move rapidly into the real-time qPCR market
- June 27, 2006
Fluidigm Secures Series E Funding from Global Asset Management Firm AllianceBernstein L.P.
- March 20, 2006
Fluidigm Signs Additional Strategic Agreements with In-Q-TEL for Continued Development of Nanofluidic-Based Sequence Detection
- January 12, 2006
Fluidigm Announces Former Intel Executive as New CFO
2005
Publications
2009
- Bujold, M., Gopalakrishnan, A., Nally, E., King-Jones, K. 2009 Nov 23. The nuclear receptor DHR96 acts as a sentinel for low cholesterol concentrations in Drosophila. Mol Cell Biol.
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- Leong, D. E., Hahn-Windgassen, A., Foygel, K., Jun, S., Behr, B., Yao, M.W.M. 2009. Morpholino-mediated gene knockdown in the early mouse embryo. Nat Prot [Protocols Network]
- Orina, J.N., Calcagno, A.M., Wu, C.P., et.al. 2009 July 7. Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database. Mol Cancer Ther. 8(7):2057-66
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- Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T., Ohteki, T. 2009 Jun. Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med. 15(6):696-700.
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- Haston, K.M., Tung, J.Y., Reijo Pera, R.A. 2009 May 21. Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro. PLoS ONE. 4(5):e5654
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- Fan, H.C., Blumenfeld, Y.J., El-Sayed, Y.Y., Chueh, J., Quake, S.R. 2009 May. Microfluidic digital PCR enables rapid prenatal diagnosis of fetal aneuploidy. Am J Obstet Gynecol. 200(5):543.e1-7
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- Berndt, J.D., Biechele, T.L., Moon, R.T., Major, M.B. 2009 May 12. Integrative analysis of genome-wide RNA interference screens. Sci Signal. 2(70):pt4.
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- Weinstein, J.A., Jiang, N., White, R.A. 3rd, Fisher, D.S., Quake, S.R. 2009 May 8. High-throughput sequencing of the zebrafish antibody repertoire. Science. 324(5928):807-10.
[Editor's Note: The SlingShot™ Kit from Fluidigm was used in this project to quantitiate samples for sequencing]
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- Bhat, S., Herrmann, J., Armishaw, P., Corbisier, P., Emslie, K.R. 2009 May. Single molecule detection in nanofluidic digital array enables accurate measurement of DNA copy number. Anal Bioanal Chem. 394(2):457-67.
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- Diehn, M., Cho, R.W., Lobo, N.A., et al. 2009 Apr 9. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 458(7239):780-3.
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- Lee, J.E., Fusco, M.L., Saphire, E.O. 2009 Apr 2. An efficient platform for screening expression and crystallization of glycoproteins produced in human cells. Nat Protoc. 4(4):592-604.
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- Farber, C.R., Aten, J.A., Farber, E.A., et al. 2009 Mar 31. Genetic dissection of a major mouse obesity QTL (Carfhg2): Integration of gene expression and causality modeling. Physiol Genomics.
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- White, R.A. 3rd, Blainey, P.C., Fan, H.C., Quake, S.R. 2009 Mar 19. Digital PCR provides sensitive and absolute calibration for high throughput sequencing. BMC Genomics. 10(1):116.
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- Yung, T.K., Chan, K.C., Mok, T.S., Tong, J., To, K.F., Lo, Y.M. 2009 Mar 15. Single-Molecule Detection of Epidermal Growth Factor Receptor Mutations in Plasma by Microfluidics Digital PCR in Non-Small Cell Lung Cancer Patients. Clin Cancer Res. 15(6):2076-2084.
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- Lo, Y.M.D. 2009 Jan. Noninvasive prenatal detection of fetal chromosomal aneuploidies by maternal plasma nucleic acid analysis: a review of the current
state of the art. BJOG. 116:152–157.
[Editor’s Note: “..automated platforms for conducting digital PCR…” referenced in this paper (p156) is the Fluidigm BioMark Real Time System and Fluidigm 12.765 Digital Arrays”]
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2008
- Foygel, K., Choi, B., Jun, S., et al., 2008 Dec 31. A Novel and Critical Role for Oct4 as a Regulator of the Maternal-Embryonic Transition. PLoS ONE.3(12): e4109.
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- Zimmermann, B.G., Grill, S., Holzgreve, W., Zhong, X.Y., Jackson, L.G., Hahn, S., 2008 Dec. Digital PCR: a powerful new tool for noninvasive prenatal diagnosis? Prenat Diagn. 28(12):1087-93.
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- Golden, T.R., Hubbard, A., Dando, C., Herren, M.A., Melov, S., 2008 Dec. Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. Aging Cell. 7(6):850-65.
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- Major, M.B., Roberts, B.S., Berndt, J.D., et al., 2008 Nov 11. New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Sci Signal. 1(45):ra12.
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- Yao, Y., Higgs, B.W., Morehouse, C., et al., 2008 Nov 5. Development of potential pharmacodynamic and diagnostic markers for anti-IFN-α monoclonal antibody trials in systemic lupus erythematosus. Human Genomics and Proteomics, 2009: 16 pages
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- Kuchenbauer, F., Morin, R.D., Argiropoulos, B., et al., 2008 Nov, In-depth characterization of the microRNA transcriptome in a leukemia progression model. Genome Res. 18(11):1787-97.
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- Chang, C.P., Nagel, D., Zaghloul, M., Nov-Dec 2008, Go with the (micro) flow. IEEE Potentials. 27(6):17-25.
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- Dube, S., Mir, A., Jones, R.C., Ramakrishnan, R., Sun, G., 2008 Oct 27. Computation of Maximal Resolution of Copy Number Variation on a Nanofluidic Device using Digital PCR. arXiv:0809.1460v2 [q-bio.GN]
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- Fan, H.C., Blumenfeld, Y.J., Chitkara, U., Hudgins, L., and Quake, S.R. 2008 Oct 21. Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood. PNAS. 105(42):16266-71.
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- Jedrusik, A., Parfitt, D.E., Guo, G., et. al., 2008 Oct 1. Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo. Genes Dev. 22(19):2692-706
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- Qin, J., Jones, R.C., Ramakrishnan, R. 2008 Oct. Studying copy number variations using a nanofluidic platform. Nucleic Acids Research. 36(18):e116.
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- Weisenberger, D.J., Trinh, B.N., Campan, M., et al. 2008 Aug. DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight. Nucleic Acids Research. 36(14):4689-98.
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- Lun, F.M., Chiu, R.W., Chan, K.C., Leung, T.Y., Lau, T.K., Lo, Y.M. 2008 Aug 14. Microfluidics Digital PCR Reveals a Higher than Expected Fraction of Fetal DNA in Maternal Plasma. Clinical Chemistry.
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- Dube, S., Qin, J., Ramakrishnan, R. 2008 Aug 6. Mathematical Analysis of Copy Number Variation in a DNA Sample Using Digital PCR on a Nanofluidic Device. PLoS ONE. 3(8): e2876.
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- Yao, Y., Richman, L., Morehouse, C., et al. 2008 Jul 16. Type I Interferon: Potential Therapeutic Target for
Psoriasis? PLoSONE. 3(7):e2737.
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- Oehler, V.G., Qin, J., Ramakrishnan, R., et. al. 2008 Jul 10. Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia using a novel nanofluidic platform and mutation-specific PCR. Leukemia.
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- Ishikawa, S., Umeda, T. 2008 May 31. Current status of CNV research and related methods. Clinical Genome Research (Japan). 229(9)
- Spurgeon, S.L., Jones, R. C., Ramakrishnan, R. 2008 Feb 27. High throughput gene expression measurement with real time PCR in a microfluidic dynamic array. PLoSONE. 3(2):e1662.
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2007
- Habicht, C., Templin, W.D., Willette, T.M., Fair, L.F., Raborn, S.W., and Seeb, L.W. 2007 Dec. Post-season stock composition analysis of Upper Cook Inlet sockeye salmon harvest, 2005-2007. Alaska Department of Fish and Game, Fishery Manuscript No.07-07, Anchorage.
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- Sindelka, R., Jonak, J., Hands, R., Bustin, S.A., and Kubista, M. 2007 Nov 26. Intracellular expression profiles measured by real-time PCR tomography in the Xenopus laevis oocyte. Nucleic Acids Research. 36(2): 387–392.
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- Fan, H.C. , Quake, S.R. 2007 Oct 1. Detection of aneuploidy with digital polymerase chain reaction. Anal. Chem. 79(19):7576-9.
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- Spletter, M.L., Liu, J., Liu, J., 2007 Jul 16, Lola regulates Drosophila olfactory projection neuron identity and targeting specificity. Neural Develop. 2:14.
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2006
- Ottesen, E.A., Hong, J.W., Quake, S.R., and Leadbetter, J.R. 2006 Dec 1. Microfluidic digital PCR enables multigene analysis of individual environmental bacteria. Science. 314(5804):1464-7.
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- Warren, L., Bryder, D., Weissman, I.L., and Quake, S.R. 2006 Nov 21.Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc. Natl. Acad. Sci. USA. 103(47):17807-12.
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2005
2004
2003
- Liu, J., Hansen, C., and Quake, S.R. 2003 Sep 15. Solving the 'world-to-chip' interface problem with a microfluidic matrix. Analytical Chemistry. 75(18): 4718-4723.
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- Wheeler, A.R., Throndset, W.R., Whelan, R.J., et al. 2003 Jul 15. Microfluidic device for single-cell analysis. Analytical Chemistry. 75(14):3581-3586.
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2002
2001
2000
- Quake, S.R. and Scherer, A. 2000 Nov 24. From micro- to nanofabrication with soft materials. Science. 290(5496):1536-1540.
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- Unger, M.A., Chou, H.P., Thorsen, T., Scherer, A., and Quake, S.R. 2000 Apr 7. Monolithic microfabricated valves and pumps by multilayer soft lithography. Science. 288(5463):113-116.
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1999
- Fu, A.Y., Spence, C., Scherer, A., Arnold, F.H., and Quake, S.R. 1999 Nov. A microfabricated fluorescence-activated cell sorter. Nature Biotechnology 17(11):1109-1111.
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- Chou, H.P., Spence, C., Scherer, A., and Quake, S. 1999 Jan 5. A microfabricated device for sizing and sorting DNA molecules. Proc. Natl. Acad. Sci. USA. 96(1):11-13.
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BioMark™ Bibliography
Gene Expression, Genotyping, Digital PCR - BioMark related journal publications.
