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TOPAZ® Software

AutoInspeX II Software Suite: Crystal Vision Software

The TOPAZ system includes the most advanced software analysis tools in the industry, including Crystal Vision software. Its advantages include:

  • Best in class crystal scoring capability
  • Images that are always in focus
  • Simple, intuitive interface

Crystal Vision software dramatically improves the efficiency of crystal analysis and scoring. Image processing software uses high-resolution data to accurately score the degree of crystallization activity and, thereby, removes much of the analysis burden typically placed on researchers. An entire series of experiments can be evaluated in one session, saving hours of inspection time.

Crystal Vision Software at a Glance
Calling accuracy: < 1% false negatives
< 5% false positives
Classification of crystals: 10 x 20 micron and larger

Activity scores for the entire 96-reagent screen can be viewed in various tabular formats (Figure 1) or as color-coded layouts of the experiments (Figure 2). This global view is helpful to rapidly determine the most promising conditions for crystallization. Images for individual chambers can be magnified and viewed side-by-side to compare changes over several time points.

If you wish to schedule a software demo, please contact your local sales representative

Crystal Vision Software Screenshots

Crystal Vision: Table View with activity scores and user annotationFig. 1. The Table View shows both Auto Calls, "Crystal" or "Ranked" according to activity score, and User Annotations. Data is displayed in an easy-to-use format that speeds comparative analyses.

Crystal Vision: Layout View with crystallization historyFig. 2. The Layout View allows quick assessment of crystallization activity across the entire chip run. Blue squares indicate chambers containing crystals. Viewing historical data allows easy comparison of results over several time points.

 

TOPAZ® Database Suite: Experiment Manager Software

The TOPAZ database suite is used to manage information from every component of the TOPAZ system through a single user-friendly interface. The advantages of the TOPAZ database include:

  • Complete data management from setup to follow on experiments
  • Easily analyze results across the entire database
  • Comprehensive web-based reports

Experiment Manager software provides the master scheduling and analysis tools to design and execute experiments from initial screening through scale-up. Image data can be sorted and/or queried by automatic or user–annotated results. The data may be compared using these queries or by referring directly to historical image data. Intuitive design wizards and templates make it easy to design follow–on experiments applicable to any crystallization method.

If you wish to schedule a software demo, please contact your local sales representative.

Experiment Manager Software Screenshots

Experiment Manager software provides master scheduling and analysis tools.Fig. 1.
Experiment Manager software automatically integrates OptiMix or third-party reagent information

Experiment Manager software provides master scheduling and analysis tools.Fig. 2.
Experiment Manager software helps you design follow-on experiments.
Experiment Manager software provides master scheduling and analysis tools.Fig. 3.
Experiment Manager software helps you to discover crystallization trends quickly using multiple parameter queries.
TOPAZ Web Reports - customized HTML reports of top crystallization activity.Fig. 4.
Database Web Reports are customized HTML reports of top crystallization activity accessible from any desktop.

Take a brief tour to discover the advantages of the TOPAZ database suite:

TOPAZ database suite demo