Immune Signatures Predict Surgery Recovery

A researcher on the fast track to developing an immune system fitness test

Stanford’s Brice Gaudillière, MD, PhD, is doing groundbreaking research in collaboration with Gabriela Fragiadakis, Robert Bruggner, Martin Angst and Garry Nolan to reveal how activation of specific cell transcription factors correlates with the speed of recovery after surgery. In this video, he shares his recent findings and offers insights about what’s behind the recent rise in mass cytometry. Gaudillière also discusses his development of a presurgical immune stress test and how barcoding can confirm whether cell changes are endogenous rather than due to lab errors.

“You know how much info you get from doing a cardiac stress test—more than a resting-state EKG. Well how about doing an immune stress test determining if you’re immunologically fit to undergo surgery?”

Time-stamped video highlights

0:07 Introduction

0:41 Applications for surgical recovery signals

1:00 CyTOF technology arrived at the perfect time

2:22 Specific cell transcription factor activation correlates with surgical recovery

2:45 Developing a presurgical immune stress test

3:30 What’s behind the recent rise in mass cytometry 

4:25 Cytometry barcoding ensures cell changes are endogenous, not lab errors

Read the September 2014 Science Translational Medicine paper,
“Clinical recovery from surgery correlates with single-cell immune signatures.”