Seminar | Advancing Human Systems Immunology

CyTOF® and Proseek Analysis of Newborn Blood Provides Novel Insights

CyTOF® and Proseek Analysis of Newborn Blood Provides Novel Insights into Immune System Development

In this presentation, recorded at the 7th Annual Mass Cytometry Summit in Prague, Dr. Petter Brodin of the Karolinska Institutet and Karolinska University Hospital in Stockholm shares his most recent research (Olin, A. et al. 2018) on stereotypic immune system development in newborn children.

Interested in understanding the factors that drive human immune variation, Brodin’s group used mass cytometry and plasma protein analysis to perform a systems-level, longitudinal analysis of blood immune cells and serum after birth.

Hear Brodin discuss:

  • technologies developed at his lab enabling analysis of small-volume blood samples
  • integration of mass cytometry data and Proseek (Olink®) plasma protein data with clinical information using a topological parameter landscaping method
  • how mass cytometry combined with other -omics approaches provided unique insights into the interplay between the environment and the immune system
  • the surprising result that the immune systems of children of different gestational ages and environmental conditions still converge on a shared developmental trajectory


Petter Brodin

Petter Brodin, MD, PhD
Assistant Professor, Science for Life Laboratory
Karolinska Institutet and Department of Neonatology
Karolinska University Hospital, Stockholm

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References

Olin, A., Henckel, E., Chen, Y. et al. “Stereotypic immune system development in newborn children.” Cell 174 (2018): 1,277–92.

Kaczorowski, K.J., Shekhar, K., Nkulikiyimfura, D. et al. “Continuous immunotypes describe human immune variation and predict diverse responses.” Proceedings of the National Academy of Sciences of the United States of America 114 (2017): E6097–106.

For Research Use Only. Not for use in diagnostic procedures.