Hear Jen Gommerman, PhD, describe how her team from Toronto University used Imaging Mass Cytometry™ (IMC™) to learn more about the poorly understood mechanisms by which cortical pathology and meningeal tertiary lymphoid tissues are involved in disease progression.
In this recorded webinar, Gommerman discusses:
- how they are optimizing and validating a panel of 33 antibodies for molecular markers of interest for use in IMC
- results from initial IMC studies to visualize disease pathology in patient brain tissue
- plans to use biospecimens from the Netherlands Brain Bank to compare MS donors to two non-MS control groups with and without meningeal inflammation
Researchers in Gommerman’s lab are aiming to shed light on the pathological processes associated with multiple sclerosis disease progression. To do this they need to look at many markers within intact tissues to understand what the immune cells are doing and how they correlate with tissue damage in the brain. Using IMC allows them to take a comprehensive approach to viewing the tissue ecosystem, with a goal of understanding the relevance of the different immune cell subsets and their location and how this relates to mechanisms in multiple sclerosis disease process. Gommerman is Professor and Graduate Coordinator at the University of Toronto in the Department of Immunology, where she spearheaded a new Applied MSc. In addition to examining the role of B lymphocytes in multiple sclerosis patients, her group focuses on how members of the TNF superfamily of molecules regulate immunity and autoimmunity. Gommerman also is the lead PI on a study to examine the effect of global migration on susceptibility to autoimmune disease.
Jen Gommerman, PhD
Professor and Associate Chair, Graduate Studies
Department of Immunology
University of Toronto
For Research Use Only. Not for use in diagnostic procedures.