Combined T cell receptor (TCR) and ATAC to allow investigation of the epigenetic landscape and the TCR simultaneously. This method allows the discovery of antigens that drive T cell fate or cis and trans regulators that drive the expansion of a T cell clone.Please use 10,000 characters max
|Cell Name||Cell Type||Source|
|CD4+ T cells||Immune||Primary|
|58alphabeta negative hybridoma||Immune||Cell line|
Applying T-ATAC seq to samples from T cell leukemia tissues enables the identification of cancer clone-specific epigenomic signatures unobservable from ensemble methods. This provides combined TCR specificity and T cell epigenomic state.
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