Biocompatible Hybrid Nanogels

Pich, A., Zhang, F., Shen, L. et al.

Various types of nanoobjects such as metal, semiconductor, and polymer particles, various types of hydrogels and polymer micelles have been incorporated into living cells. [1] Many of these experiments were directed to cell imaging or drug delivery whereas others were intended to introduce optical sensors into the cells.[2] Many types of nanoparticles need to be surface-modified or encapsulated by inert material to avoid cytotoxicity, and the nature of the modified surface must be appropriate to promote uptake of these particles by cells. We are interested in lanthanide (Ln) NPs,[3] employed as tags and designed for elemental analysis using Inductively Coupled Mass Spectrometer (ICP-MS). These NPs are known for their unique optical properties and have been considered as promising materials for biodiagnostic purposes.[4] In our work, the elemental composition of NPs and signal intensity indicate their type and number, respectively and are used to bar code live cells.


Pich, A., Zhang, F., Shen, L. et al. "Biocompatible Hybrid Nanogels" Small (2008): 2,171–5