Publications

Genomic landscape of CD34+ hematopoietic cells in myelodysplastic syndrome and gene mutation profiles as prognostic markers

Xu, L., Gu, Z.H., Zhang, J.L., Chang, C.K., Pan, C.M., Shi, J.Y., Shen, Y., Chen, B., Wang, Y.Y., Jiang, L., Lu, J., Xu, X., Tan, J.L., Chen, Y., Wang, S.Y., Li, X., Chen, Z., Chen, S.J.

Myelodysplastic syndrome (MDS) represents a common hematopoietic disease, often in elderly patients, with heterogeneous clinical phenotypes and complex disease mechanisms. Here, we report on characteristic genome lesions, clonal architecture, and distinct tumor clone expansion patterns in a group of patients with refractory anemia with excess blasts, the MDS subtype with the highest propensity to acute myeloid leukemia. An integrative gene mutation analysis in 196 patients with different MDS subtypes allowed a regulatory network of mutually cooperative or exclusive molecules to be discovered among eight functional categories, whereas the combination of a panel of marker genes of prognostic value with the revised-International Prognostic Scoring System may provide a better stratification system for MDS.

Citation

Xu, L., Gu, Z.H., Zhang, J.L., Chang, C.K., Pan, C.M., Shi, J.Y., Shen, Y., Chen, B., Wang, Y.Y., Jiang, L., Lu, J., Xu, X., Tan, J.L., Chen, Y., Wang, S.Y., Li, X., Chen, Z., Chen, S.J. "Genomic landscape of CD34+ hematopoietic cells in myelodysplastic syndrome and gene mutation profiles as prognostic markers" Proceedings of the National Academy of Sciences of the United States of America (2014): 8,589–94