Publications

Molecular landscape of acute promyelocytic leukemia at diagnosis and relapse

Fasan, A., Haferlach, C., Perglerovà, K. et al.

Acute promyelocytic leukemia (APL) occurs in about 5–30% of adult de novo AML and is characterized by the presence of the chromosomal translocation t(15;17)(q24;q21). The resulting PML-RARA chimeric gene involves the retinoic acid receptor alpha-(RARA) gene on chromosome 17 and the PML gene, a putative transcription factor, on chromosome 15. The resulting PML-RARA chimeric protein is crucial to the pathogenesis of APL as it is thought to contribute two oncogenic hits in one: the block of differentiation and the aberrant self-renewal of APL cells.

Citation

Fasan, A., Haferlach, C., Perglerovà, K. et al. "Molecular landscape of acute promyelocytic leukemia at diagnosis and relapse" Haematologica (2017): e222–4