Publications

T-cell phenotyping uncovers systemic features of atopic dermatitis and psoriasis

Farrera, C., Melchiotti, R., Petrov, N., et al.

Atopic dermatitis (AD) and psoriasis are T-cell–mediated, chronic inflammatory skin conditions, which are increasingly recognized as systemic rather than localized cutaneous diseases. Hence, a deeper understanding of the phenotypic and functional features of the circulatory T-cell compartment may offer novel insights into their pathogenesis, generate opportunities for novel targeted therapies, as well as aid in the identification of potential biomarkers. We and others have previously performed fluorescence-based immunophenotyping of circulatory T cells in psoriasis and AD,1 and an earlier comparative study highlighted distinctive features of systemic activation in T cells of patients with AD.

Citation

Farrera, C., Melchiotti, R., Petrov, N., et al. "T-cell phenotyping uncovers systemic features of atopic dermatitis and psoriasis" Journal of Allergy and Clinical Immunology (2019): 31623–9