American Association for Cancer Research

April 18 - 22, 2015 | Pennsylvania Convention Center, Philadelphia

American Association for Cancer Research

April 18, 2015

Pennsylvania Convention Center, Philadelphia

Register

The foundations of cancer start as a complex interplay between environmental exposure to carcinogens and inherited susceptibility. As cancers progress, heterogeneity increases, creating rare treatment resistant sub-clones with mutational profiles extending beyond even the broadest cancer panels. Without accurately determining how the unique mutations within rare sub-clones affect gene expression and cell function, translational discoveries won’t make it from the bench to the bedside.

You can now unravel cancer complexity by analyzing individual cancer cells at the DNA, RNA, and Protein level, and challenge single-cells with functional studies to determine their biological function. By studying cancer from every angle, you can discover novel biomarkers, build accurate panels, and evaluate the effects of immunotherapy on individual cells.

By enabling single-cell genomic, transcriptomic, proteomic, and functional studies, Fluidigm’s Ideal Lab creates new approaches for cancer breakthroughs. Join us in the Ideal Lab at AACR 2015 booth #763 to learn how you can study cancer from every angle, and rapidly take your research from bench to bedside.

With Fluidigm, Cancer complexity is only in the biology.

 

Panel Discussion and Mixer

Translating single-cell discoveries into precision therapies
Join us for a panel discussion to learn how the leading single-cell researchers are developing accurate, personalized cancer models.

Del Frisco’s Wine Vault Map
Monday, April 20, 6:00–9:00 pm
Drinks and heavy appetizers will be served 

 

 

Ideal Lab

Fluidigm’s complete end-to-end workflows, single-cell resolution, and high quality data allow you to examine cancer at every angle, and make revolutionary discoveries with confidence.

Juno™
Discovery starts with authenticated cell lines

 

C1™
Characterize tumor heterogeneity at single-cell DNA and RNA level

 

CyTOF® 2
Identify novel tumor and immune response biomarkers with single-cell proteomic profiling

 

Polaris™
Dose and measure the molecular response of individual cancer cells.

 

Access Array™ on Juno
Predict tumorigenesis, therapy response, and discover biologically relevant genes by screening up to 5,000 loci.

 

 

2015 AACR Posters & Presentations

City Date Venue Registration
Richard M. Neve Cell line authentication to improve preclinical cancer research: Methods in cell line authentication, quality control, and annotation. Saturday, April 18, 2:00–2:25 PM Room 108, Pennsylvania Convention Center
Michitaka Nakano, Hiroshi Ariyama, Shingo Tamura, et al. Plasticity of CD44+ colorectal cancer stem cells depends on TGF-beta-induced epithelial mesenchymal transition (EMT): evidences from ex vivo culture system Monday, April 20, 8:00 AM –12:00 PM Section 19-19, Abstract #1520
Christopher B. Benton, Ahmed Al Rawi, Taejin Min, et al. Single cell analysis of Lin-CD34-CD45- cells from primary AML samples reveals leukemia clones with stem cell-like properties distinct from CD34+CD38-CD123+ LSC Monday, April 20, 8:00 AM–12:00 PM Section 15-3, Abstract #1391
Benton et al. GD2+ breast cancer stem cell growth is dependent on NFκB signaling and suppressed by the IKK inhibitor BMS345541 in vitro and in vivo. Monday, April 20, 8:00 AM–12:00 PM Section 19-27, Abstract #1528
Paul Savage, Sadiq M. Saleh, Ernesto Iacucci, et al. Identifying tumor subpopulations and the functional consequences of intratumor heterogeneity using single-cell profiling of breast cancer patient-derived xenografts Monday, April 20, 1:00 PM–5:00 PM Section 41, Abstract #LB-129
Erin F. Simonds, Garry P. Nolan, William A. Weiss et al. Characterizing intratumoral cellular heterogeneity in human glioblastoma xenografts by 30+ parameter single-cell mass cytometry Monday, April 20, 1:00–5:00 PM Section 17-4, Abstract #2313
Jennifer J. Brady, Chen-Hua Chuang, Deborah R. Caswell, et al. Mechanisms governing lung adenocarcinoma metastasis Monday, April 20, 1:00–5:00 PM Section 15-6, Abstract #2255
Jakubicova et al. Phenotypic and molecular characterization of inter- and intraclonal heterogeneity in multiple myeloma and Waldenstrom macroglobulinemia.   Monday, April 20, 1:00–5:00 PM Section 5-11, Abstract #2004
Henry King, Helen Payne, Tim Brend, et al. Radioresistance in glioma stem cells driven by Rad51 dependent homologous recombination repair Tuesday, April 21, 8:00 AM–12:00 PM Section 18-8, Abstract #3303
Huanhuan Mahsa He, Feiqiao Brian Yu, Stephen R. Quake, et al. Single cell analysis of ascites macrophages in ovarian cancer Tuesday, April 21, 8:00 AM–12:00 PM Section 14-14, Abstract #3202
Emily Putnam, Lam Nguyen, Hunter Chung, et al. A targeted bisulfite sequencing method combining microfluidics-based PCR with Next-Gen sequencing Tuesday, April 21, 8:00 AM–12:00 PM Section 3-14, Abstract #2956
Max S. Wicha Breast cancer stem cell state transitions mediate therapeutic resistance Tuesday, April 21, 11:40–11:55 AM Terrace Ballroom II-III (400 Level), Abstract #SY27-03
Marco A. De Velasco, Yurie Kura, Naomi Ando, et al. Inhibition of mouse PTEN-deficient prostate cancer with next generation antisense oligonucleotide targeting the androgen receptor Tuesday, April 21, 1:00–5:00 PM Section 20-27, Abstract #4212
Mohammad Fallahi-Sichani, Nathan J. Moerke, Mario Niepel, et al. Single-cell analysis of adaptive resistance and fractional responses of melanoma cells to RAF/MEK inhibition Tuesday, April 21, 1:00–5:00 PM Section 1-1, Abstract #3744
Shamileh Fouladdel, Hyeun Joong Yoon, Eric Lin, et al. Gene expression signatures of isolated circulating tumor cells from metastatic breast cancer patients reveal presence of breast cancer stem cells with EMT or MET phenotypes Tuesday, April 21, 4:20–4:35 PM Room 118, Abstract #4726
Erica B. Schleifman, Maipelo Motlhabi, Craig Cummings, et al. Comparison of gene expression platforms: RNA-Seq, Fluidigm, and Nanostring Wednesday, April 22, 8:00 AM–12:00 PM Section 6-24, Abstract #4901
John B. Williamson, Hongyong Zhang, Paul Lott, et al. A comparison of bulk versus single-cell whole-exome sequencing to study cancer genetic heterogeneity Wednesday, April 22, 8:00 AM–12:00 PM Section 3-30, Abstract #4820
Ebrahim Azizi, Evelyn M. Jiagge, Shamileh Fouladdel, et al. Single cell multiplex gene expression analysis to unravel heterogeneity of PDX samples established from tumors of breast cancer patients with different ethnicity Wednesday, April 22, 8:00 AM–12:00 PM Section 4-118, Abstract #4834
Jun Wang, Guoli Li, Ming Chen, et al. High-throughput mutation sequencing of the full exon regions in BRCA1 and BRCA2 genes using nanofluidic-PCR prepared libraries Wednesday, April 22, 8:00 AM –12:00 PM Section 6-16, Abstract #4893

Social Media

Challenge your colleagues to use single-cell methods in their cancer research in the Ideal Lab. Record your challenge to be shared on Twitter and a $10 donation to the American Association of Cancer Researchers will be made in your name.


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