Imaging Mass Cytometry
Gain unprecedented insights from highly multiplexed single-cell spatial biology
Imaging Mass Cytometry™ (IMC™) is a vital tool that allows researchers to gain an appreciation of the role of heterogeneity in cell function and assess complex phenotypes and tumor-immune interactions in the tissue and tumor microenvironment. Gain a deeper understanding of the spatial environment to answer important translational and clinical research questions in the context of disease.
When speed matters, get faster answers for cohort analysis and clinical studies with the second-generation Hyperion+™ Imaging System.
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Workflow
1
Design
Design panels using pathologist-verified Maxpar® antibodies conjugated to metal tags.
2
Stain
Stain tissues (FFPE or frozen) using familiar IHC protocols.
3
Image
Image up to 40 protein markers at single-cell resolution using the Hyperion™ Imaging System.
4
Analyze
Analyze images in minutes using the MCD™ Viewer and easily export for secondary analysis.
Using the Hyperion Imaging System, you can visualize the complex spatial biology of the tissue microenvironment with Imaging Mass Cytometry.
- Single-cell resolution: allows accurate and quantifiable phenotyping and cell function assessment
- No autofluorescence: reliable results when working with highly autofluorescent tissues like lung, gut, brain and skin
- No time-consuming cyclic protocols: high-plex protein detection from formalin-fixed, paraffin-embedded or frozen tissue sections
- Proven: hundreds of hands-on users and more than 130 peer-review published references
Expert insight on the transformation of precision medicine
Olivier Elemento, PhD
Professor, Physiology and Biophysics, Weill Cornell Medicine
Director, Englander Institute for Precision Medicine
Oliver Elemento shares his expert insight on the transformation of precision medicine. In this short video, Elemento describes why artificial intelligence, high-throughput sequencing and Imaging Mass Cytometry are becoming increasingly critical tools for personalizing treatments and improving patient outcomes.
Publications
Keep current with how Imaging Mass Cytometry (IMC) is used to gain deep spatial insights – see articles, news, bibliographies, tips and more. Check out the IMC Trending Topics and Publications.
IMC TRENDING TOPICS & PUBLICATIONS
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Applications
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Join the hundreds of researchers globally who are using Imaging Mass Cytometry to phenotype the tissue microenvironment, stratify samples and discover biomarkers to gain therapeutic insights that address significant translational and clinical research questions.
See more than 130 publications
Apr 08 - Apr 13
Location
AACR Annual Meeting 2022 (American Association for Cancer Research) in New Orleans, LA
Mar 27 - Mar 30
Location
ABRF (Association of Biomolecular Resource Facilities) in Palm Springs, CA
Mar 23
Webinar
Sample Tracking in Genomic Workflows Using the Biomark ™ X System and New Analysis Pipeline Software
Jun 21 - Jun 23
Location
Sequencing to Function: Analysis and Applications for the Future (SFA²F) in Santa Fe, NM
Oct 12 - Oct 14
Location
NERLSCD 2022 (Northeast Regional Laboratory Staff & Core Directors) in Rochester, NY
Sep 16 - Sep 18
Location
GLIIFCA XXXI (Great Lakes International Imaging and Flow Cytometry Association) in Indianapolis, IN
Apr 27
Virtual
Scientist in the Spotlight - Receptor Occupancy - Gerd Bringeland and Sonia Gavasso "Monitoring antibody therapies – bead based receptor occupancy quantitation in mass cytometry"
Jun 03 - Jun 07
Location
CYTO 2022 (International Society for Advancement of Cytometry ) in Philadelphia, PA
Jun 13 - Jun 16
Location
CROPS 2022 - Huntsville, AL
Jun 21
Virtual
Mega Insights with Microfluidics 2022: Roundtable Discussion on Biomark™ X
Sep 21 - Sep 22
Location
WACD 2022 (Western Association of Core Directors) at the California NanoSystems Institute at UC Los Angeles
Sep 19 - Sep 20
Location
Forum LABO in Lyon, France
Mar 25
Virtual
GEN: Single-Cell Immune Profiling Can Help Resolve Tumor Microenvironment Complexities
Apr 25
Webinar
CAP Today: Innovations in Immune Profiling for Clinical Research
Apr 08
Virtual
Scientist in the Spotlight - Nicole Strittmater "Multimodal imaging strategies to increase our understanding of drug delivery"
May 18
Virtual
Scientist in the Spotlight in collaboration with the EACR - Bernd Bodenmiller "Multiscale Analysis of Tumor Ecosystems Towards Precision Medicine"
Jun 07
Virtual
Scientist in the Spotlight - Ilaria Michelozzi High-dimensional functional phenotyping of preclinical human CAR T cells using mass cytometry
May 24
Webinar
Save the Date: Igniting Insight in Immuno-Oncology CyTOF® Flow Cytometry Virtual Summit
Jun 14
Webinar
Cytometry Powered by Time-of-Flight: Igniting Insight into Immuno-Oncology: CyTOF Summit, Tuesday, June 14
Jun 15
Webinar
Cytometry Powered by Time-of-Flight: Igniting Insight into Immuno-Oncology: IMC Forum, Wednesday, June 15
Nov 13 - Nov 14
Physical-and-Virtual
SITC 2021 (Society for Immunotherapy of Cancer) in Washington, DC
Nov 01 - Nov 03
Virtual
Frontiers in Cancer Science 2021
Gerard Evan
Jesús Gil Valles
Thomas Gajewski
Apr 14
Virtual
Scientist in the Spotlight - Simon Cabello and Julie Vendrell-"Theranostic, prognostic and diagnostic uses of a flexible Solid Tumor NGS library prep assay in a university hospital
Nov 04
Virtual
Scientist in the Spotlight with Corinne Ramos from ImaBiotech
Corinne Ramos
Apr 25
Webinar
IMC Forum 2022: Current Methods and Future Views for Effective Cell Segmentation in High-plex Imaging
Jul 12
Webinar
Imaging Mass Cytometry™ Master Class: IMC Image Basics and Image Processing with MCD Viewer
Lindsy Rapkin, PhD
Jul 20 - Jul 22
Location
FlowCytometry UK in Birmingham, UK
Sep 21 - Sep 24
Location
ESCCA (European Society for Clinical Cell Analysis) in Bellfast, UK
Sep 21 - Sep 22
Location
International Spatial Biology Congress in The Hague, The Netherlands
Oct 21
Virtual
IMC Summit: Uncovering Spatial Biology
Chris Linthwaite
Melissa Davis, PhD
Bernd Bodenmiller, PhD
Resources
Flyers & brochures
Spotlight articles
Application notes
Technical documents
Protocols
Unless explicitly and expressly stated otherwise, all products are provided for Research Use Only, not for use in diagnostic procedures. Find more information here.