Products & Services Technologies Imaging Mass Cytometry IMC Trending Topics and Publications

IMC Trending Topics and Publications

You want to get the most out of your precious samples, to answer complex questions through deep interrogation and analysis of relevant data, to understand the role of spatial biology in health and disease and to publish and showcase your research results.


The Power of IMC

Learn how Imaging Mass Cytometry™ (IMC™) is used as a vital spatial biology tool.

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IMC Trending Topics

IMC Trending Topics articles, toolbox and news feature the great work performed by IMC users.

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IMC Publications

Find the most current bibliography and charts that demonstrate the published use of IMC.

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The Power of IMC

  • ­­Subcellular resolution: allows accurate and quantifiable phenotyping and cell function assessment

  • No autofluorescence: reliable results when working with highly autofluorescent tissues like lung, gut, brain and skin

  • No time-consuming cyclic protocols: high-plex protein detection from formalin-fixed, paraffin-embedded or frozen tissue sections

  • Proven: hundreds of hands-on users and more than 130 peer-review published references




Click Phenotype, Stratify and Discover to view each of these value application areas.

IMC Trending Topics Toolbox

Recommended resources grouped to provide you with knowledge, ideas and tips on selected topics.

Staining for tissue imaging on the Hyperion™ Imaging System is similar to standard immunohistochemistry techniques in terms of tissue collection, tissue processing and the staining itself. Optimized staining is important in order to carry out extensive characterization of the tissue microenvironment. There are numerous examples of panels of up to 40 markers described for formalin-fixed, paraffin-embedded (FFPE) human tumor sections, and a protocol for frozen tissue sections is also available.  

Featured NEWS

IMC Trending Topics News

Check this feature regularly to see a current selection of exciting news and stories about researchers who are using IMC to make an impact.



  • Congratulations to Mathieu Lajoie at the Goodman Cancer Institute, McGill University, whose spatial graph image is on the April 2022 Science Immunology cover!
    Mathieu is an author on the recent paper, Spatially mapping the immune landscape of melanoma using Imaging Mass Cytometry, in which the team used IMC to characterize the immune microenvironment of melanoma patient samples, allowing for the identification of prognostic biomarkers for immunotherapy.
  • ImaBiotech will present a new "Immune Signature Panel" as part of its Imaging Mass Cytometry Services at the AACR22 meeting in New Orleans. Read the news!


  • Here’s a great read about the IMMUcan project and how researchers are working toward highly personalized tumor profiling for cancer patients. Daniel Schulz, PhD, and the project team use IMC to generate images from small tissue sections and have developed an approach to zoom in on select regions that capture the immune cell heterogeneity.


  • In early February, the winners of the 2022 Terry Fox New Investigator Award were announced. One of the winners is Hartland Jackson, PhD, an investigator at the Lunenfeld-Tanenbaum Research Institute at Sinai Health. With this grant, Jackson’s team will use IMC, digital pathology and systems biology to better understand how the Hippo pathway controls immune response to cancer.

  • Researchers from the King’s College London Schools of Cancer and Pharmaceutical Sciences and Immunology and Microbial Sciences and the Cancer Systems Biology laboratory at the Francis Crick Institute, led by Francesca Ciccarelli, PhD, have developed a new software for the analysis of data from multiplexed imaging technologies such as IMC. “When we started to work with high-dimensional IMC data a couple of years ago, there were not many tools for their analysis,” Ciccarelli says. “It has been a lot of fun to develop our own tool thanks to the talent of Michele Bortolomeazzi, a PhD student” funded by the Cancer Research UK King's Health Partners Centre.

IMC Publications

Join the hundreds of researchers gaining deep spatial insights using Imaging Mass Cytometry.

Get the complete IMC bibliography now, with over 130 peer-reviewed publications.

See more than 130 Publications

Get a list of more than 50 publications about the use of high-plex imaging by IMC to investigate the spatial biology of the complex tumor microenvironment and its role in furthering immuno-oncology research.

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As of December 31, 2021, there are 138 total peer-reviewed publications for IMC, with 63 from 2021, more than double the number added in 2020.

Immuno-oncology and cancer were the leading category with 37% of IMC publications in this research area. In addition to IMC being used in a wide range of applications, significant work has been done to develop methods and data analysis approaches.

Unless explicitly and expressly stated otherwise, all Fluidigm products are provided for Research Use Only, not for use in diagnostic procedures. For more information see