The Future is Functional Genomics
Imagine if you could explore the genomes of every cell to find the gene networks that regulate them. You could correlate a cell’s phenotype, physiological condition and molecular signature to discover the genetic circuits regulating cell function or compare a population’s sensitivity to environmental changes. It’s the future of single-cell biology, and it’s available now on Polaris™, the first system to seamlessly integrate cell and molecular biology at the single-cell level. Select individual cells, challenge them with factors you choose under strict environmental conditions for up to 24 hours and measure each cell’s acute response transcriptionally via next-generation sequencing. And because it all happens on one precisely designed IFC, controlled by an intuitive touchscreen interface, all that’s left to the imagination is what question you’ll answer next.
PreciseSelect your target cell by phenotype, viability or transgenic reporter. |
SeamlessSelect, dose and prepare cells for analysis in one integrated workflow. |
InteractiveObserve and manipulate cells in their biological environment. |
FlexibleChallenge cells with a variety of parameters with the tap of a touchscreen. |
Technology
An innovative integrated fluidic circuit (IFC) enables Polaris to actively select single cells from heterogeneous cell samples and hold them in individual, environmentally controlled reaction chambers. Once isolated, cells can be challenged with a variety of factors, including transcription factors, RNAs and small molecules, at the dosage or intervals you define. Then the cells are automatically lysed and RNA template is prepared for mRNA sequencing analysis. Polaris does it all in a single IFC and with minimal hands-on time, controlled by an elegant, intuitive touchscreen interface.
Workflow
Support
components
IFCs, Assays and Reagents
Related Systems
Software
Specifications
Dimensions as Shipped
Height | 42.0 in (106.8 cm) |
Width | 28.6 in (72.7 cm) |
Depth | 37.3 in (94.8 cm) |
Weight | 300 lb (136 kg) |
Uncrated
Height | 27.8 in (70.6 cm) |
Width | 20.6 in (52.2 cm) |
Depth | 34.1 in (86.6 cm) |
Weight | 242 lb (110 kg) |
Site Requirements
Clearance | 6 in (15 cm) from the rear |
Temperature | 15–28 ºC (59–82 ºF) stable |
Humidity | 30–80%, noncondensing |
Altitude site preparation | <8,202 ft (2,500 m) |
Components
Current | 10 A (max) |
Voltage | 90 V (min) to 240 V (max) |
Frequency | 50/60 Hz |
Main supply fluctuation | not to exceed ±10% of the nominal supply voltage |
Connection | 4x USB 2.0 |
Humidity | 30–80%, noncondensing |
Gas Requirements
Grade | Clean, dry premixed gas (standard grade) |
Blood gas | 5% CO2, 5% oxygen and 90% nitrogen |
Mixed gas | 5% CO2, 20% oxygen and 75% nitrogen |
Regulatory | 22–25 psi |