Product

Consumables

Maxpar® Human Treg Phenotyping Panel Kit, 13 Markers—25 Tests

Regulatory T cells (Tregs) are a suppressive subset of CD4+ T helper (Th) cells important for the regulation of immune responses. Tregs are defined by expression of the transcription factor Foxp3. Additional Treg markers include constitutive expression of the high-affinity IL-2Rα chain (CD25) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), along with low expression of the IL-7Rα chain (CD127). CD4+CD25+ Foxp3+ Tregs can be divided into 2 main types: thymically derived Tregs (tTregs) and peripherally derived Tregs (pTregs). Although it is difficult to distinguish between tTregs and pTregs phenotypically, both are thought to have an essential role in immune regulation. Because of their immunoregulatory function, Tregs are an attractive therapeutic target in many different immune-mediated diseases, including transplantation, autoimmunity, and autoinflammation.

Target

Clone

Metal

CD49D 9F10 141Pr
CD4 RPA-T4 145Nd
CCR4 L291H4 149Sm
CD45RA HI100 153Eu
CD3 UCHT1 154Sm
CD39 A1 160Gd
Foxp3 PCH101 162Dy
CD95 DX2 164Dy
CD45RO UCHL1 165Ho
CD25 2A3 169Tm
CD152 14D3 170Er
HLA-DR L243 174Yb
CD127 A019D5 176Yb
  • Species:
    Human
  • Clone:
    No.72-1
  • Markers:
    13

 

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