SHP-2, also known as PTPN11, is a widely expressed non-receptor protein tyrosine phosphatase and adapter protein. SHP-2 participates in diverse signaling cascades, including JAK-STAT, and PI3K/Akt pathways, and most prominently the Ras/MAPK pathway. SHP-2 is activated by phosphorylation at Tyr542 and Tyr580 downstream of binding of growth factors such as FGF and PDGF. Unlike most phosphatases, activated SHP-2 promotes, rather than inhibits, downstream intracellular signaling. The exact mechanism of this functionality remains unclear. Mutations in SHP-2 are associated with excessive Ras/MAPK pathway activation in several hematopoietic malignancies, including Noonan syndrome and juvenile myelomonocytic leukemia.
Anti-pSHP2 [Y580](D66F10)-141Pr—50 Tests