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Anti-Cleaved Caspase 3 (D3E9)-142Nd—50 Tests

Caspase-3 (CPP32/Yama/apopain ) is a 32 kDa cysteine protease that is activated during the early stages of apoptosis. Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments, which associate to form the active enzyme. Caspase-3 is either partially or totally responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP). Caspase-3 expression is widely distributed. Cells of lymphoid origin express high levels, and active caspase-3 is a marker for cells undergoing apoptosis. Caspase-3 also plays an important role in morphogenetic cell death during development of the mammalian brain. The 5A1E antibody reacts with the active cleaved form of caspase-3.

  • Species:
    Cross
  • Clone:
    D3E9
  • Target:
    Caspase 3/Cleaved
  • Tag:
    142Nd

 

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