CrkL is an adapter protein that links signaling components such as tyrosine kinases and small G proteins. CrkL is involved in regulation of diverse cellular processes, including cytokine responses, cell adhesion, cell migration, and immune activation. CrkL is required for activity of the oncogenic BCR-ABL fusion protein and is phosphorylated at Tyr207 in chronic myeloid leukemia neutrophils, but not in healthy neutrophils. Overexpression of CrkL in human bronchial epithelial cells promotes cell proliferation and cyclin expression. CrkL is closely related to CrkII, and this antibody cross-reacts with CrkII phosphorylated at Tyr221.
Anti-pCrkl [Y207] (polyclonal)-143Nd—50 Tests