GITR (glucocorticoid-induced TNFR family gene) and its ligand (GITRL) are induced upon activation of a number of immune cell types. GITR is expressed at low levels on resting T cells, but its expression is rapidly increased upon activation. Although constitutively expressed on Foxp3+ regulatory T cells (Tregs), GITR is dispensable for Treg function. GITR-deficient mice are viable, reproduce normally, and have no obvious immunological defects in the naive state. Studies using GITR-deficient mice or an agonist anti-GITR antibody have shown an immune-stimulatory role for GITR in the context of viral infections.
Anti-Mouse CD357/GITR (DTA1)-143Nd—100 Tests
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Species:Mouse
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Clone:DTA1
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Target:CD357/GITR
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Tag:143Nd
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Quantity:100 Tests
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