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Anti-Mouse CD115 (AFS98)-144Nd—100 Tests

CD115 is encoded by the c-fms proto-oncogene and belongs to the class III receptor tyrosine kinase family. CD115 is a cell surface receptor identified for colony-stimulating factor-1 (CSF-1), a major cytokine regulating differentiation, proliferation, and migration of myeloid lineage cells. CD115 is expressed by monocyte, macrophage, osteoclast, and some epithelial cells. IL-34 has more recently been identified as another CD115 ligand with comparable biological effects. In humans, CD115 and CSF-1 overexpression are frequent in a wide variety of epithelial tumors and have been correlated with more aggressive diseases and poor prognosis.

  • Species:
    Mouse
  • Clone:
    AFS98
  • Target:
    CD115
  • Tag:
    144Nd

 

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