HVEM is a protein of the TNFR superfamily that serves as a shared ligand for co-stimulatory and co-inhibitory receptors. HVEM was named for the ability of types 1 and 2 herpesvirus gD to bind to it for viral entry into the cell. HVEM not only interacts with viral gD proteins, but also binds receptors in the Ig superfamily, including BTLA and CD160, and receptors in the TNF superfamily, including LIGHT and LTα. Ligation of HVEM on T cells by membrane-bound LIGHT delivers positive signals through HVEM, whereas engagement of by HVEM provides negative signals to T cells via BTLA/CD160. HVEM receptor expression is distributed widely on hematopoietic and nonhematopoietic cells. Besides T and B cells, HVEM is expressed on dendritic cells, monocytes, neutrophils, NK cells, and nonhematopoietic cells including parenchymal cells.
Anti-Human CD270/HVEM (122)-144Nd—100 Tests