CD43, also known as leukosialin, is a highly glycosylated 125 kDa type I transmembrane protein with a mucin-like structure expressed in all immune cells except naïve B lymphocytes. It was long considered to be exclusively expressed in cells from the hematopoietic and immune system. However, more recent reports underscore a role for CD43 in nonimmune cells, including tumor cells, and in rat kidney and brain epithelium. CD43 is reported to bind to CD54 and to play a role in adhesion and B cell survival. Studies of CD43-deficient mice indicate that CD43 participates in the negative regulation of T cell activation and adhesion.
Anti-Mouse CD43 (S11)-146Nd—100 Tests