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Anti-Human CD182/CXCR2 (5E8/CXCR2)-147Sm—100 Tests

CD182, also known as CXCR2 or IL-8 receptor B (IL-8RB), is a 67–70 kDa member of the 7-transmembrane-spanning G protein-coupled receptor (GPCR) family. CD182 is expressed as a homodimer, or a heterodimer with CD181 (CXCR1, IL-8RA), and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes, and oligodendrocytes. CD182 mediates neutrophil activation and chemotaxis, megakaryocytic proliferation, and angiogenesis upon binding its ligands including IL-8 (CXCL8), NAP-2 (CXCL7), GCP-2 (CXCL6), and GRO-α,β,γ (CXCL1, CXCL2, CXCL3).

  • Species:
    Human
  • Clone:
    5E8/CXCR2
  • Target:
    CD182
  • Tag:
    147Sm

 

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