CD172b, also known as signal-regulatory protein β (SIRPβ), is a type I transmembrane protein belonging to the SIRP family within the Ig superfamily. It contains a single-pass transmembrane region with immunoglobulin-like domains. Unlike CD172a, this receptor lacks a cytoplasmic SHP-2 binding domain. CD172b is expressed on cells of monocyte, macrophage or dendritic lineages. CD172a and CD172b are based on the putative structures of their C-terminal intracellular domains, which distinguish them as either activating (CD172b) or inhibitory (CD172a) isoforms. They have complementary roles in signal regulation and may work together in tuning the response to a stimulus.
Anti-Human CD172b (B4B6)-149Sm—100 Tests