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Anti-pRb [S807/S811] (J112-906)-150Nd—50 Tests

The retinoblastoma (RB) gene encodes a phosphoprotein that negatively regulates the cell cycle. This activity is critical for the classic RB-mediated tumor suppression function. Mutations in the retinoblastoma susceptibility gene lead to childhood retinal cancer, and the RB pathway is altered in 70% of human cancer types. Upon mitogenic signaling, RB protein is inhibited by hyperphosphorylation, which disrupts RB transcriptional repression complexes to allow G1 to S phase transition. RB also induces S phase arrest, triggered by the intra-S phase checkpoint in the presence of DNA-damaging agents, such as cisplatin and VP-16. RB also participates in other cellular processes, such as terminal cell differentiation and maintenance of genetic stability. It has also been suggested that RB can exert an anti-apoptotic function and that RB is cleaved by caspases during apoptosis induced by VP-16 and tumor necrosis factor-α (TNF-α).

  • Species:
    Cross
  • Clone:
    J112906
  • Target:
    pRb [S807/811]
  • Tag:
    150Nd

 

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