CD103, also known as integrin alpha E (ITGAE), is a type I transmembrane integrin protein that binds integrin beta 7 to form the integrin αEβ7. CD103 is expressed on intraepithelial lymphocyte (IEL) alpha-beta and gamma-delta T cells, a subset of regulatory T (Treg) cells, lamina propria T cells, and a subset of dendritic cells. CD103 has also been used as a marker to identify hairy cell leukemia. CD103 is the primary ligand for E-cadherin, an adhesion molecule found on epithelial cells. It is likely that this interaction plays a role in T cell homing to intestinal sites. Stimulation of human T cells induces up-regulation of CD103.
Anti-Human CD103 (Ber-ACT8)-151Eu—100 Tests