p38 MAP kinase is a member of the mitogen activated protein kinase (MAPK) family of serine/threonine protein kinases. It is involved in responses to cellular stresses such as inflammatory cytokines, bacterial lipopolysaccharide, UV exposure, osmotic shock, and growth factors. p38 exists in 4 isoforms, p38a (MAPK14), p38β (MAPK11), p38γ (MAPK12), and p38δ (MAPK13). Upstream kinases MKK3, SEK1/MKK4, and MKK6 can activate the p38 isoforms through dual phosphorylation of Thr180 and Tyr182. Activated p38 transmits the signal to immediate targets including MAPKAPK2 and HSP27. The subsequent activation of transcription factors (i.e., ATF2, MEF2, and TCF) results in up-regulation of genes related to a stress response, such as proinflammatory cytokines.
Anti-p38 [T180/Y182] (D3F9)-156Gd—50 Tests