SR-AI, also known as type I class A macrophage scavenger receptor (MSR-AI), is a 70–80 kDa protein that belongs to the transmembrane scavenger receptor (SR) family. The human gene for SR-A gives rise to 3 alternatively spliced isoforms (I, II, and II). SR-AI is a type II transmembrane glycoprotein containing an N-terminal cytoplasmic domain, transmembrane domain, spacer domain, α-helical coiled coil domain, collagen-like domain, and C-terminal cysteine-rich domain. SR-As are expressed by most tissue macrophages and dendritic cells. SR-As bind a broad range of polyanionic ligands and therefore have been implicated in many physiological and pathophysiological functions.
Anti-Human SR-AI/MSR (351615)-156Gd—100 Tests