Members of the signal transducer and activator of transcription (STAT) family are important intracellular messengers of cytokines and growth factor signaling. Seven mammalian STATs have been identified: STAT1–4, 5a, 5b and 6. STAT proteins are activated by tyrosine phosphorylation, which causes dimerization and translocation to the nucleus, where the STAT dimer acts as a transcription factor. JAK-mediated phosphorylation of Tyr705 on STAT3 occurs in response to many cytokines and growth factors including interferon-alpha, EGF, IL-5, IL-6, G-CSF and HGF. Activated STAT3 promotes transcription of genes that mediate cell growth and differentiation.
Anti-Human/Mouse pStat3 [Y705] (4/P-STAT3)-158Gd—25 µg