Consumables

Anti-pStat3 [Y705] (4/P-STAT3)-158Gd

Members of the signal transducer and activator of transcription (STAT) family are important intracellular messengers of cytokines and growth factor signaling. Seven mammalian STATs have been identified: STAT1–4, 5a, 5b and 6. STAT proteins are activated by tyrosine phosphorylation, which causes dimerization and translocation to the nucleus, where the STAT dimer acts as a transcription factor. JAK-mediated phosphorylation of Tyr705 on STAT3 occurs in response to many cytokines and growth factors including interferon-alpha, EGF, IL-5, IL-6, G-CSF and HGF. Activated STAT3 promotes transcription of genes that mediate cell growth and differentiation.

  • Species:
    Human
  • Clone:
    4/P-STAT3
  • Target:
    Phospho-Stat3
  • Tag:
    158Gd
  • Quantity:
    25µg
  • Sample Type:
    FFPE

 

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