CD73, also known as ecto-5'-nucleotidase, is a 70 kDa glycophosphatidylinositol (GPI)-linked 5'-nucleotidase. CD73 is expressed on bone marrow-derived multipotent mesenchymal stem cells (MSCs) and is one of the 3 positive markers for identifying MSCs. CD73 is expressed on subsets of follicular dendritic cells, epithelial cells, endothelial cells and T and B lymphocytes, where its expression increases during lymphocyte maturation. CD73 catalyzes the dephosphorylation of adenosine monophosphate (AMP), converting it to adenosine. There is also evidence that CD73 can mediate costimulatory signals in T cell activation and adhesion of lymphocytes to endothelium.
Anti-Human CD73 (EPR6115)-158Gd—25 µg