The 621 monoclonal antibody reacts with human GITR (glucocorticoid-induced TNF receptor family-regulated gene), also known as AITR (activation-inducible TNFR family member), or CD357. GITR is an approximately 25 kDa member of the TNFR superfamily. Reports in the literature suggest that GITR signaling can regulate T cell proliferation and TCR-mediated apoptosis. GITR associates with TRAF1, TRAF2 and TRAF3 and induces nuclear factor NF-κB activation via TRAF2. GITR binds GITRL/AITRL to mediate the development of regulatory T cells and to regulate the activity of T cell Th1 subsets.
Anti-Human CD357 (621)-159Tb—100 Tests
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Species:Human
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Clone:621
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Target:CD357/GITR
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Tag:159Tb
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