PDGFRα (platelet-derived growth factor receptor alpha), also known as CD140a, is a 170 kDa single transmembrane glycoprotein expressed on a variety of cells including fibroblasts, smooth muscle cells, glial cells, and chondrocytes. PDGFRα forms a receptor for PDGF family proteins as either a homodimer or as a heterodimer with PDGFRβ. Proteins of the PDGF family exist as several dimeric isoforms (PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC, and PDGF-DD) that bind in a specific manner to PDGF receptors. PDGFRα and PDGFRβ can also form heterodimers with EGFR, which is also activated by PDGF family proteins. Ligand-binding to PDGF receptors initiates multiple cellular functions including cell growth, actin reorganization, migration, and differentiation.
Anti-Human PDGFRa (D13C6)-160Gd—50 Tests