Death receptor 3 (DR3), also known as Wsl-1, Apo3, LARD, TRAMP and TR3, is a member of the tumor necrosis factor (TNF) receptor superfamily and is a major regulator of inflammation and autoimmune diseases. DR3 contains a homologous intracellular region called the death domain (DD) that can bind adapter proteins, which also contain a DD, initiating cellular responses such as caspase activation and apoptotic cell death. In other circumstances, DR3 can initiate induction of transcription that can prevent cell death from occurring. DR3 is expressed at low levels by monocytes and granulocytes.
Anti-Human DR3 (JD3)-161Dy—100 Tests