Antibody clone RPA-T8 recognizes CD8a, which is an isoform of CD8. CD8, also known as T8 and Leu2, is a type I membrane glycoprotein. CD8 is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I, and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
Anti-Human CD8a (RPA-T8)-162Dy—100 Tests
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Species:Human
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Clone:RPAT8
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Target:CD8a
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Tag:162Dy
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Quantity:100 Tests
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