The LN2 monoclonal antibody binds specifically to CD74, a type II transmembrane glycoprotein also known as MHC class II-associated invariant chain, MHC class II chaperone and MIF receptor. CD74 has four isoforms of 33 kDa, 35 kDa, 41 kDa and 43 kDa, which are splice variants. CD74 is weakly expressed on B cells, monocytes and macrophages. Reports have also shown CD74 expression on Langerhans cells, dendritic cells, some activated T cells and thymic epithelium. CD74 is primarily thought to function as an intracellular sorter of MHC class II molecules and regulator of exogenous peptide loading onto MHC class II. There have also been reports showing that CD74 is involved in positive selection of CD4+ T cells and modulation of B cell differentiation.
Anti-Human CD74 (LN2)-166Er—25 µg