The DX9 monoclonal antibody specifically binds to CD158e1, also known as NKB1. CD158e1 is a 70 kDa member of the immunoglobulin superfamily that is expressed on a subset of natural killer cells and T cells. CD158e1 functions as a killer cell inhibitory receptor (KIR) and is encoded by KIR3DL1 (killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail). Interaction of CD158e1 with specific HLA-B antigen on a target cell has been reported to inhibit cell-mediated cytotoxicity by delivering a negative signal that limits lymphocyte activation. It is suggested that this MHC class I-KIR interaction acts to regulate NK and T cell responses to antigenic challenge.
Anti-Human NKB1 (DX9)-167Er—100 Tests