The Y9A2 monoclonal antibody binds to human integrin α9β1, a transmembrane protein belonging to the integrin family. Multiple ligands bind to integrin α9β1, including the inducible endothelial counterreceptor, vascular cell adhesion molecule-1 (VCAM-1), the extracellular matrix proteins tenascin-C and osteopontin, coagulation factor XIII, and von Willebrand factor. Integrin α9β1 is expressed on a variety of cell types including airway epithelium cells, different types of muscle cells, and hepatocytes. In blood, integrin α9β1 is highly expressed on human neutrophils and at low level on monocytes. Recent reports have found integrin α9β1 expression on hematopoietic stem and progenitor cells, where it is thought to mediate stem cells adhesion, proliferation, and differentiation.
Anti-Human Integrin a9b1 (Y9A2)-168Er—100 Tests