Nanog is a homeobox-containing transcription regulator involved in inner cell mass (ICM) and embryonic stem (ES) cell proliferation and self-renewal. Functionally, Nanog works together with other key pluripotent factors such as Oct4 and Sox2 to control reprogramming of differentiated cells to an induced pluripotent stem cell state. Cell differentiation can proceed once Nanog expression is down-regulated. Proteins that regulate Nanog expression include transcription factors Oct4, Sox2, FoxD3, and Tcf3 and tumor suppressor p53.
Anti-Human Nanog (N31-355)-169Tm—50 Tests