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Anti-EGFR (D38B1)-169Tm—50 Tests

Epidermal growth factor receptor (EGFR), also known as ErbB-1 and HER1 in humans, is a transmembrane glycoprotein that is a member of the protein kinase superfamily for cell growth and differentiation regulation. EFGR is an extracellular protein ligand that binds to epidermal growth factor and transforming growth factor α (TGFα). Ligand binding induces receptor dimerization and tyrosine autophosphorylation, initiating the MAPK , Akt, and JNK signal transduction pathways towards DNA synthesis and cell proliferation. EGFR is expressed or highly expressed in a variety of human tumors of epithelial origin.

  • Species:
    Cross
  • Clone:
    D38B1
  • Target:
    EGFR
  • Tag:
    169Tm

 

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