Epidermal growth factor receptor (EGFR), also known as ErbB-1 and HER1 in humans, is a transmembrane glycoprotein that is a member of the protein kinase superfamily for cell growth and differentiation regulation. EFGR is an extracellular protein ligand that binds to epidermal growth factor and transforming growth factor α (TGFα). Ligand binding induces receptor dimerization and tyrosine autophosphorylation, initiating the MAPK , Akt, and JNK signal transduction pathways towards DNA synthesis and cell proliferation. EGFR is expressed or highly expressed in a variety of human tumors of epithelial origin.
Anti-Human EGFR (AY13)-170Er—100 Tests