CD154, also known as CD40 ligand (CD40L), is a 39 kDa type II membrane glycoprotein of the TNF family. It has been reported that CD154-binding with its ligand, CD40, is required for the proteolysis of membrane-bound CD154 and the subsequent release of soluble CD154 (sCD154) by activated platelets. Soluble CD154 is an 18 kDa fragment comprised of residues 113–261 of the membrane-bound CD154 molecule and remains a functional trimer retaining its ability to bind receptors. The CD154 homotrimer is nonconstitutively expressed on different cell types, including activated T lymphocytes, basophils, eosinophils, monocytes, macrophages, natural killer cells, B lymphocytes, platelets, and dendritic, endothelial, smooth muscle, and epithelial cells. Accumulating evidence indicates that CD154 can bind to receptors other than CD40, namely, the integrins αIIbβ3, α5β1, and αMβ2.
Anti-Mouse CD154/CD40 Ligand (MR1)-170Er—100 Tests