B7-H3 is a type I transmembrane protein belonging to the B7 family of cell surface ligands that regulate T cell activation and immune responses. Its expression can be found on antigen-presenting cells such as dendritic cells and macrophages, activated T cells and natural killer cells. B7-H3 is expressed in a few normal tissues, including placenta and prostate; in several cancer types, including prostate, breast, colon, lung and gastric cancers; and in endothelial cells from tumor-associated vasculature. It has been reported that B7-H3 acts as a negative regulator of T cell response by inhibiting T cell proliferation.
Anti-Human CD276/B7-H3 (Polyclonal)-173Yb—25 µg