The 6D4 monoclonal antibody reacts with the human major histocompatibility complex (MHC) class I chain-related (MIC) MICA and MICB proteins, also known as PERB11.1 and PERB11.2. MICA and MICB are 65–75 kDa, highly polymorphic, stress-inducible glycoproteins. MICA and MICB possess 83% amino acid similarity and show homology with classical human leukocyte antigen (HLA) molecules. The structure of MICA and MICB is similar to classical HLA class I chains. However, they do not bind β2 microglobulin or bind peptide typical of HLA class I. MICA and MICB act as a ligand for NKGD2 expressed on the surface of NK cells, γδ T cells, and αβ CD8+ T cells. Furthermore, they are expressed on endothelial cells, fibroblasts, gastric epithelium cells, and PHA-stimulated T cells. Reports have shown that human cytomegalovirus (HCMV) subverts NK cell detection by inhibiting the function of MICB. MICA and MICB expression has been detected in epithelial tumors from the breast, lung, ovary, prostate, colon, and kidney.
Anti-Human MIC A/B (6D4)-174Yb—100 Tests