CD196, also known as CC-chemokine receptor type 6 (CCR6), is expressed on immature dendritic cells, B lymphocytes and memory T cells. CCR6-positive cells and its ligand CCL20 have been detected in numerous organs, especially the secondary lymphoid organ. It can mediate the arrest of T cells and has been reported to be highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have also been implicated in the pathogenesis of various inflammatory autoimmune diseases, playing a role in the recruitment of Th17 cells.
Anti-Human CD196/CCR6 (G034E3)-176Yb—50 Tests