306 results found in Imaging Mass Cytometry
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Publications
Simultaneous Multiplexed Imaging of mRNA and Proteins with Subcellular Resolution in Breast Cancer Tissue Samples by Mass Cytometry
To build comprehensive models of cellular states and interactions in normal and diseased tissue, genetic and proteomic information must be extracted with single-cell and spatial resolution. …
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Publications
High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
Individual reports suggest that the central nervous system (CNS) contains multiple immune cell types with diverse roles in tissue homeostasis, immune defense, and neurological diseases. …
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consumable
Imaging Mass Cytometry
Reagents for deep interrogation of tissues and tumors …
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Publications
Ruthenium Counterstaining for Imaging Mass Cytometry
Imaging mass cytometry is a novel imaging modality that enables simultaneous antibody-based detection of more than 40 epitopes and molecules in tissue sections at subcellular resolution using isotopically pure metal tags. …
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Publications
Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma
Yttrium-90 (Y90)-radioembolisation (RE) significantly regresses locally advanced hepatocellular carcinoma and delays disease progression. …
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Publications
Compensation of signal spillover in suspension and Imaging Mass Cytometry
The advent of mass cytometry increased the number of parameters measured at the single-cell level while decreasing the extent of crosstalk between channels relative to dye-based flow cytometry. …
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Publications
Opposing Roles of Dendritic Cell Subsets in Experimental GN
Dendritic cells (DCs) are thought to form a dendritic network across barrier surfaces and throughout organs, including the kidney, to perform an important sentinel function. …
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event
Imaging Mass Cytometry User Group Meeting
2nd Annual Imaging Mass Cytometry User Group Meeting …
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media
Seminar | Uncovering Cellular Networks
Analysis of Tissue Ecosystems in Health and Disease by Imaging Mass Cytometry …
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media
Seminar | Advancing Translational and Clinical Research
Imaging Mass Cytometry to Characterize the Tumor Immune Microenvironment …
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consumable
Anti-Human Smooth Muscle Actin (1A4)-141Pr—25 µg
Alpha smooth muscle actin is a 42 kDa cytoskeletal protein expressed in smooth muscle cells of blood vessels, myofibroblasts and myoepithelial cells. …
Product #: 3141017D
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consumable
Anti-Human p53 (DO-7)-143Nd—25 µg
p53 is a 53 kDa protein that operates as a tumor suppressor and helps regulate hundreds of genes in response to various types of stress. …
Product #: 3143026D
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consumable
Anti-Vimentin (D21H3)-143Nd—25 µg
Vimentins are class-III intermediate filaments found in various nonepithelial cells, especially mesenchymal cells. …
Product #: 3143027D
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consumable
Anti-pTyrosine (P-Tyr-100)-144Nd—25 µg
Tyr100 recognizes phosphorylated tyrosine residues in all proteins. An increase in total cellular phosphotyrosine levels indicates a shift in the balance of tyrosine protein kinases and phosphases. …
Product #: 3144024D
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consumable
Anti-Human T-bet/TBX21 (D6N8B)-145Nd—25 µg
T-bet (Tbx21) is a transcription factor bearing a T-box DNA-binding domain. It is considered a master-regulator of the Th1 CD4+ T cell subset. …
Product #: 3145015D
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consumable
Anti-Human/Mouse BCL-6 (K112-91)-147Sm—25 µg
BCL-6 is expressed in B and T cells. In B cells, BCL-6 induces proliferation, antibody class switching, and affinity maturation. In T cells, BCL-6 is required for programming of TFH cell generation. …
Product #: 3147020D
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consumable
Anti-p4E-BP1 [T37/T46] (236B4)-149Sm—25 µg
4E-BP1, also known as PHAS-1, is a member of the 4E-BP (eIF4E-binding protein) family of translational repressors, which also includes 4E-BP2 and 4E-BP3. …
Product #: 3149023D
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consumable
Anti-Human Syk (4D10.2)-149Sm—25 µg
Syk is a cytoplasmic 72 kDa nonreceptor tyrosine kinase that plays an important role in intracellular signal transduction in hematopoietic cells. …
Product #: 3149024D
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consumable
Anti-Human CD15 (W6D3)-149Sm—25 µg
CD15, also known as LewisX, 3-FAL and SSEA-1, is a carbohydrate adhesion molecule, 3-fucosyl-N-acetyllactosamine (3-FAL). …
Product #: 3149026D
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consumable
Anti-Human/Mouse CD11b (EPR1344)-149Sm—25 µg
CD11b, also known as Mac-1, is a transmembrane glycoprotein known to be involved in cell adhesion and phagocytosis. …
Product #: 3149028D