364 results found in Single-Cell Genomics

• Publications

  Power analysis of single-cell RNA-sequencing experiments

  …

• Publications

  RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection

  Latent viral infection is a persistent cause of human disease. Although standard antiviral therapies can suppress active viral replication, no existing treatment can effectively eradicate latent infection and therefore a cure is lacking for many prevalent viral diseases. …

• Publications

  A multi-scale approach reveals that NF-κB cRel enforces a B-cell decision to divide

  Understanding the functions of multi-cellular organs in terms of the molecular networks within each cell is an important step in the quest to predict phenotype from genotype. …

• product insert

  C1 Reagent Kit for Preamplification Product Insert 

  This kit is used to facilitate the capture of cells and performing preamplification on single cells or for targeted gene expression analysis.

• system

  Polaris

  Seamless integration of cell biology and molecular analysis at the single-cell level …

• media

  A Novel, Multifactorial Approach for hiPSC Differentiation and Reprogramming Using an Automated Cell Culture System 

  A major challenge in the stem cell field is to define the optimal condition for cell expansion, differentiation and reprogramming.

• Publications

  Effect of cryopreservation on delineation of immune cell subpopulations in tumor specimens as determinated by multiparametric single cell mass cytometry analysis

  Comprehensive understanding of cellular immune subsets involved in regulation of tumor progression is central to the development of cancer immunotherapies. …

• User Guide

  Targeted Sequencing Preparation with Juno Getting Started Guide 

  Getting Started Guide

• Publications

  Single-Cell Multiomics: Multiple Measurements from Single Cells

  Single-cell sequencing provides information that is not confounded by genotypic or phenotypic heterogeneity of bulk samples. …

• technical note

  Cell Sorting Directly to the C1 IFC Application Note 

  Sorting directly into the C1 IFC cell inlet can be a very effective strategy for obtaining a rare subpopulation of cells with high purity and viability from a larger population.

• technical note

  Single-Cell Genomics in Immunology Technical Note 

  Gene expression profiling at the single-cell level is possible with both targeted and whole transcriptome approaches, such as qPCR and mRNA sequencing (mRNA seq).

• article

  What’s New for C1 Applications on Script Hub

  View the growing list of community-developed apps for single-cell biology …

• article

  Exploring Diversity with Single-Cell Clarity

  Confidently scale your cell atlas or lineage study with the new C1 medium-cell HT IFC …

• article

  Amplify Your Productivity

  With more than 1,000 publications and counting, Biomark is a rising star in PCR …

• Protocol

  C1 System for mRNA Seq Protocol 

  Using C1 to Generate Single-Cell cDNA Libraries for mRNA Sequencing

• Publications

  Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation

  Differentiation of lymphocytes is frequently accompanied by cell cycle changes, interplay that is of central importance for immunity but is still incompletely understood. …

• Publications

  Live single-cell laser tag

  The ability to conduct image-based, non-invasive cell tagging, independent of genetic engineering, is key to cell biology applications. …

• Publications

  Brain trauma elicits non-canonical macrophage activation states

  Macrophage polarization programs, commonly referred to as “classical” and “alternative” activation, are widely considered as distinct states that are exclusive of one another and are associated with different functions such as inflammation and wound healing, respectively. …

• Publications

  The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar

  Pancreatic Lgr5 expression has been associated with organoid-forming epithelial progenitor populations but the identity of the organoid-initiating epithelial cell subpopulation has remained elusive. …

• Publications

  The first five years of single-cell cancer genomics and beyond

  Single-cell sequencing (SCS) is a powerful new tool for investigating evolution and diversity in cancer and understanding the role of rare cells in tumor progression. …