5693 results found
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Technology to watch in 2018
Thought leaders reveal the technologies and topics likely to transform life-science research in the year ahead. …
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Simultaneous Multiplexed Imaging of mRNA and Proteins with Subcellular Resolution in Breast Cancer Tissue Samples by Mass Cytometry
To build comprehensive models of cellular states and interactions in normal and diseased tissue, genetic and proteomic information must be extracted with single-cell and spatial resolution. …
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A computational approach for phenotypic comparisons of cell populations in high-dimensional cytometry data
Cytometry is an experimental technique used to measure molecules expressed by cells at a single cell resolution. …
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Impact of recent innovations in the use of mass cytometry in support of drug development
Cytometry by time-of-flight (CyTOF) is a novel technology for the real-time analysis of single cells. …
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CyTOF® supports efficient detection of immune cell subsets from small samples
Analysis of immune cell states is paramount to our understanding of the pathogenesis of a broad range of human diseases. …
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Mass cytometry assays for antigen-specific T cells using CyTOF®
T cells specific for a single antigen tend to be rare, even after expansion of memory cells. …
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CyTOF® mass cytometry for click proliferation assays
Novel cell analyzers, including polychromatic flow cytometers and isotopical cytometry by time of flight (CyTOF) mass cytometers, enable simultaneous measurement of virtually bondless characteristics at the single-cell level. …
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Applications of mass cytometry in clinical medicine: the promise and perils of clinical CyTOF®
Mass cytometry is a novel technology similar to flow cytometry in which antibodies are tagged with heavy metal molecules rather than fluorophores and then detected with time-of-flight mass spectrometry. …
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Atomic mass tag of bismuth-209 for increasing the immunoassay multiplexing capacity of mass cytometry
Mass cytometry (or CyTOF) is an atomic mass spectrometry-based single-cell immunoassay technology, which has provided an increasingly systematic and sophisticated view in basic biological and clinical studies. …
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Gating mass cytometry data by deep learning
Mass cytometry or CyTOF is an emerging technology for high-dimensional multiparameter single cell analysis that overcomes many limitations of fluorescence-based flow cytometry. …
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Analyzing the phenotypic and functional complexity of lymphocytes using CyTOF® (cytometry by time-of-flight)
Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes. …
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By CyTOF®: heterogeneity of human monocytes
Human monocyte subsets have traditionally been defined based on expression of CD14 and CD16 into classical, nonclassical, and intermediate monocytes. …
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CyTOF® measurement of immunocompetence across major immune cell types
The central role of the immune system is becoming appreciated in a wide variety of diseases. …
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A CD45-based barcoding approach to multiplex mass-cytometry (CyTOF®)
CyTOF enables the study of the immune system with a complexity, depth, and multidimensionality never achieved before. …
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RNA-Seq and CyTOF® immuno-profiling of regenerating lacrimal glands identifies a novel subset of cells expressing muscle-related proteins
The purpose of the present studies was to use CyTOF and RNA-Seq technologies to identify cells and genes involved in lacrimal gland repair that could be targeted to treat diseases of lacrimal gland dysfunction. …
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Research techniques made simple: experimental methodology for single-cell mass cytometry
Growing recognition of the complexity of interactions within cellular systems has fueled the development of mass cytometry. …
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Single-cell mass cytometry of acute myeloid leukemia and leukemia stem/progenitor cells
Mass cytometry time-of-flight (CyTOF) empowers us to understand acute myeloid leukemia (AML) biology at the single-cell level. …