411 results found for "macrophage"
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Publications
Single-cell analysis reveals new subset markers of murine peritoneal macrophages and highlights macrophage dynamics upon Staphylococcus aureus peritonitis
Resident macrophages play a central role in maintaining tissue homeostasis and immune surveillance. …
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Cracking the Immunity Code
Oxford scientists discern macrophage signaling roles in HIV latency using Polaris …
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Publications
Brain trauma elicits non-canonical macrophage activation states
Macrophage polarization programs, commonly referred to as “classical” and “alternative” activation, are widely considered as distinct states that are exclusive of one another and are associated with different functions such as inflammation and wound healing, respectively. …
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A Systematic Approach to Identify Markers of Distinctly Activated Human Macrophages
Polarization has been a useful concept for describing activated macrophage phenotypes and gene expression profiles. …
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Publications
Origin, fate and dynamics of macrophages at CNS interfaces
Perivascular, meningeal and choroid plexus macrophages are non-parenchymal macrophages that mediate immune responses at brain boundaries. …
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Specific Macrophage Subtypes Influence the Progression of Rhabdomyolysis-Induced Kidney Injury
Rhabdomyolysis can be life threatening if complicated by AKI. …
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PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage cell lines treated with either IFNγ or IL-4, that PARP9 and PARP14 regulate macrophage activation. …
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Publications
Guardians of the Gut – Murine Intestinal Macrophages and Dendritic Cells
Intestinal mononuclear phagocytes find themselves in a unique environment, most prominently characterized by its constant exposure to commensal microbiota and food antigens. …
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Regulation of Activation-associated MicroRNA Accumulation Rates during Monocyte-to-macrophage Differentiation
Circulating monocytes recruited to tissues can differentiate into macrophages and adopt unique gene expression programs in response to environmental cues. …
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Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages
Macrophages are cells with remarkable plasticity. …
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Lipid Droplet Formation, Their Localization and Dynamics during Leishmania major Macrophage Infection
Leishmania, the causative agent of vector-borne diseases, known as leishmaniases, is an obligate intracellular parasite within mammalian hosts. …
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Transcriptomic Signature of Leishmania Infected Mice Macrophages: A Metabolic Point of View
We analyzed the transcriptional signatures of mouse bone marrow-derived macrophages at different times after infection with promastigotes of the protozoan parasite Leishmania major. …
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Coordinated Changes in AHRR Methylation in Lymphoblasts and Pulmonary Macrophages from Smokers
Smoking is associated with a wide variety of adverse health outcomes including cancer, chronic obstructive pulmonary disease, diabetes, depression and heart disease. …
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Publications
Adipose-derived mesenchymal stromal cells modulate tendon fibroblast responses to macrophage-induced inflammation in vitro
Macrophage-driven inflammation is a key feature of the early period following tendon repair, but excessive inflammation has been associated with poor clinical outcomes. …
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Diverse in vivo effects of soluble and membrane-bound M-CSF on tumor-associated macrophages in lymphoma xenograft model
Macrophage colony-stimulating factor (M-CSF) is an important cytokine for monocyte/macrophage lineage. …
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Publications
Triggering Dectin-1-Pathway Alone Is Not Sufficient to Induce Cytokine Production by Murine Macrophages
β-glucans (BG) are abundant polysaccharides of the Saccharomyces cerevisiae cell wall (Sc CW), an industry byproduct. …
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Publications
Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells
Differentiated macrophages can self-renew in tissues and expand long-term in culture, but the gene regulatory mechanisms that accomplish self-renewal in the differentiated state have remained unknown. …
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Pyroptosis of resident macrophages differentially orchestrates inflammatory responses to Staphylococcus aureus in resistant and susceptible mice
The relationship between Staphylococcus aureus and innate immunity is highly complex and requires further investigation to be deciphered. i.p. challenge of C57BL/6 and DBA/2 mice, resistant and susceptible to the infection, respectively, resulted in different patterns of cytokine production and neutrophil recruitment. …
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Monocytic MKP-1 Is a Sensor of the Metabolic Environment and Regulates Function and Phenotypic Fate of Monocyte-Derived Macrophages in Atherosclerosis
Diabetes promotes the S-glutathionylation, inactivation and subsequent degradation of mitogen-activated protein kinase phosphatase 1 (MKP-1) in blood monocytes, and hematopoietic MKP-1-deficiency in atherosclerosis-prone mice accelerates atherosclerotic lesion formation, but the underlying mechanisms were not known. …