Fluidigm continues to team up with researchers around the world who are working to mount an aggressive and sustainable response to the COVID-19 pandemic. Below are publications, posters, recorded webinars and seminars with presentations and other resources relevant to COVID-19 research.
- SARS-CoV-2-specific T cells exhibit unique features characterized by robust helper function, lack of terminal differentiation, and high proliferative potential
Neidleman, J. et al. bioRxiv (2020): doi.org/10.1101/2020.06.08.138826.
- The inhibition of IL-2/IL-2R gives rise to CD8+ cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia
Shi, H. et al. Cell Death & Disease (2020): 429.
- Suppressive myeloid cells are a hallmark of severe COVID-19
Schulte-Schrepping, J. et al. medRxiv (2020): doi.org/10.1101/2020.06.03.20119818.
- Systems-level immunomonitoring from acute to recovery phase of severe COVID-19
Rodriguez, L. et al. medRxiv (2020): doi.org/10.1101/2020.06.03.20121582.
- Emergence of low-density inflammatory neutrophils correlates with hypercoagulable state and disease severity in COVID-19 patients
Morrissey, S. et al. medRxiv (2020): doi.org/10.1101/2020.05.22.20106724.
- High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients
Wang, W. et al. Cellular & Molecular Immunology (2020): 650–652.
- Impaired type I interferon activity and exacerbated inflammatory responses in severe COVID-19 patients
Hadjadj, J. et al. medRxiv (2020): doi.org/10.1101/2020.04.19.20068015.
- Down-regulated gene expression spectrum and immune responses changed during the disease progression in COVID-19 patients
Ouyang, Y. et al. Clinical Infectious Diseases (2020): ciaa462.
- Inflammatory response cells during acute respiratory distress syndrome in patients with coronavirus disease 2019 (COVID-19)
Zhang, Y. et al. Annals of Internal Medicine 11 (2020): doi: 10.7326/L20-0227.
- Transplantation of ACE2– mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia
Leng, Z. et al. Aging and Disease 11 (2020): 216–228.
- Identification of human immune cell subtypes most vulnerable to IL-1b-induced inflammatory signaling using mass cytometry
Kothari, H. et al. bioRxiv (2020): doi.org/10.1101/2020.04.19.047274
This issue of the quarterly anthology focuses on use of CyTOF technology to profile and monitor the immune system in translational and clinical research. In addition to reading overviews of six clinical trial-related publications, you can learn about the 10,000 Immunomes Project, an open access database of the healthy human immunome containing mass cytometry data from more than 500 subjects.
- Bringing the Power of CyTOF to COVID-19 Research. | Andrew Quong and Roberto Spada, both from Fluidigm, present on current use of mass cytometry in COVID-19 investigations.
- Profiling of COVID-19 Patient Immune Responses | Ruth Montgomery uses systems profiling to capture immune response to infection
- Mapping Dynamic Immunity across Time, Space, and Disease State | Tom Ashhurst uses mass cytometry and Imaging Mass Cytometry to better understand viral diseases of the central nervous system.
- Signatures of Protective NK Cell Responses | Catherine Blish describes her work to reveal the vast diversity of the NK repertoire
- Systems-Level Immunomonitoring with Petter Brodin | Systems-level immunomonitoring in human subjects
- Linking T Cell Exhaustion to Disease with Mass Cytometry | Disease-specific features of exhausted CD8 T cells revealed
A Multi-Omic Approach to Detection and Characterization of Viral Pathogens and Their Impact on the Immune System
Andrew Quong, PhD
Chief Science Officer
Bill Hunt, MS
Director, Microfluidics Product Management
Detection of Human and Viral Full-Length RNA Using a Nanoscale Microfluidic Platform
Steve Kain, PhD, MBA
Director, Genomics Product Management