Anti-Human CD206/MMR (15-2)-168Er—100 Tests

CD206 is a 162–175 kDa mannose receptor C-type lectin cell surface protein that belongs to a family of C-type lectin receptors (CLRs). CLRs are crucial in recognition of complex glycan structures on various pathogens and have evolved to facilitate the endocytosis and presentation of pathogens. CD206 contains 8 C-type lectin-like domains (CTLD) and acts as a phagocytic receptor for bacteria, fungi, and other pathogens. CTLD4, 5, and 7 are required for high-affinity binding and endocytosis of multivalent glycoconjugates. Studies have demonstrated that immature monocyte derived dendritic cells (MDDCs), bone-marrow derived DCs (BMDCs), and macrophages mediate, via CD206, the uptake of diverse native allergens and subsequent allergic sensitization as well as allergen-induced T cell polarization. MDDCs from allergic patients have been shown to be more efficient in antigen uptake via CD206 than those from healthy individuals.

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    100 Tests


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